The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 561600 of 1,208 generic medicines
Ethinyl Estradiol; Norelgestromin — full profile
Ethinyl Estradiol; Norelgestromin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethinyl Estradiol; Norethindrone — full profile
Ethinyl Estradiol; Norethindrone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethinyl Estradiol; Norethindrone Acetate — full profile
Ethinyl Estradiol; Norethindrone Acetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethinyl Estradiol; Norgestimate — full profile
Ethinyl Estradiol; Norgestimate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethinyl Estradiol; Norgestrel — full profile
Ethinyl Estradiol; Norgestrel
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethosuximide — full profile
Ethosuximide
Succinimide derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
44
abandoned
Etodolac — full profile
Etodolac
Acetic acid derivatives and related substances
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.0M
people
63
abandoned
Etomidate — full profile
Etomidate
Other general anesthetics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
44
abandoned
Etravirine — full profile
Etravirine
Non-nucleoside reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Everolimus — full profile
Everolimus
Mammalian target of rapamycin (mTOR) kinase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.9M
people
25
abandoned
Exemestane — full profile
Exemestane
Aromatase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
44
abandoned
Exenatide Synthetic — full profile
Exenatide Synthetic
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ezetimibe — full profile
Ezetimibe
Combinations of various lipid modifying agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.9M
people
55
abandoned
Ezetimibe; Simvastatin — full profile
Ezetimibe; Simvastatin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Famciclovir — full profile
Famciclovir
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Famotidine — full profile
Famotidine
H2-receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.7M
people
86
abandoned
Famotidine; Ibuprofen — full profile
Famotidine; Ibuprofen
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Febuxostat — full profile
Febuxostat
Preparations inhibiting uric acid production
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.0M
people
17
abandoned
Felbamate — full profile
Felbamate
Other antiepileptics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
34
abandoned
Felodipine — full profile
Felodipine
Beta blocking agents and calcium channel blockers
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
59
abandoned
Fenofibrate — full profile
Fenofibrate
Combinations of various lipid modifying agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.4M
people
17
abandoned
Fenoprofen Calcium — full profile
Fenoprofen Calcium
Propionic acid derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Fentanyl — full profile
Fentanyl
Opioid anesthetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
27
abandoned
Fentanyl Citrate — full profile
Fentanyl Citrate
Opioid anesthetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
0
abandoned
Ferric Carboxymaltose — full profile
Ferric Carboxymaltose
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ferric Citrate — full profile
Ferric Citrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ferumoxytol — full profile
Ferumoxytol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fesoterodine Fumarate — full profile
Fesoterodine Fumarate
Drugs for urinary frequency and incontinence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.2M
people
13
abandoned
Fexofenadine Hydrochloride — full profile
Fexofenadine Hydrochloride
Other antihistamines for systemic use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
40
abandoned
Fexofenadine Hydrochloride; Pseudoephedrine Hydrochloride — full profile
Fexofenadine Hydrochloride; Pseudoephedrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fidaxomicin — full profile
Fidaxomicin
Antibiotics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Finasteride — full profile
Finasteride
Other dermatologicals
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.7M
people
52
abandoned
Finasteride; Tadalafil — full profile
Finasteride; Tadalafil
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fingolimod Hydrochloride — full profile
Fingolimod Hydrochloride
Sphingosine-1-phosphate (S1P) receptor modulators
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.3M
people
17
abandoned
Flavoxate Hydrochloride — full profile
Flavoxate Hydrochloride
Drugs for urinary frequency and incontinence
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Flecainide Acetate — full profile
Flecainide Acetate
Antiarrhythmics, class Ic
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.2M
people
48
abandoned
Floxuridine — full profile
Floxuridine
Pyrimidine analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Fluconazole — full profile
Fluconazole
Imidazole and triazole derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.0M
people
63
abandoned
Flucytosine — full profile
Flucytosine
Other antifungals for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
28.1M
people
34
abandoned
Fludarabine Phosphate — full profile
Fludarabine Phosphate
Purine analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
54
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.