The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 841880 of 1,208 generic medicines
Methylprednisolone Acetate — full profile
Methylprednisolone Acetate
Corticosteroids, potent (group III)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
52
abandoned
Methylprednisolone Sodium Succinate — full profile
Methylprednisolone Sodium Succinate
Corticosteroids, potent (group III)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
34
abandoned
Methyltestosterone — full profile
Methyltestosterone
3-oxoandrosten (4) derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
9
abandoned
Metoclopramide Hydrochloride — full profile
Metoclopramide Hydrochloride
Propulsives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
32.9M
people
25
abandoned
Metolazone — full profile
Metolazone
Sulfonamides, plain
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Metoprolol Succinate — full profile
Metoprolol Succinate
Beta blocking agents and calcium channel blockers
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
25
abandoned
Metoprolol Tartrate — full profile
Metoprolol Tartrate
Beta blocking agents and calcium channel blockers
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
63
abandoned
Metronidazole — full profile
Metronidazole
Combinations for eradication of Helicobacter pylori
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
32
abandoned
Metyrosine — full profile
Metyrosine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Mexiletine Hydrochloride — full profile
Mexiletine Hydrochloride
Antiarrhythmics, class Ib
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
52
abandoned
Micafungin Sodium — full profile
Micafungin Sodium
Other antimycotics for systemic use
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
32
abandoned
Midodrine Hydrochloride — full profile
Midodrine Hydrochloride
Adrenergic and dopaminergic agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Miglitol — full profile
Miglitol
Alpha glucosidase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.8M
people
2
abandoned
Miglustat — full profile
Miglustat
Various alimentary tract and metabolism products
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.0M
people
0
abandoned
Milrinone Lactate — full profile
Milrinone Lactate
Phosphodiesterase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.0M
people
55
abandoned
Minocycline Hydrochloride — full profile
Minocycline Hydrochloride
Antiinfectives and antiseptics for local oral treatment
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
40
abandoned
Minoxidil — full profile
Minoxidil
Pyrimidine derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
75
abandoned
Mirabegron — full profile
Mirabegron
Drugs for urinary frequency and incontinence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.5M
people
9
abandoned
Mirtazapine — full profile
Mirtazapine
Other antidepressants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.0M
people
55
abandoned
Misoprostol — full profile
Misoprostol
Propionic acid derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.8M
people
19
abandoned
Mitomycin — full profile
Mitomycin
Other cytotoxic antibiotics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
1.7M
people
9
abandoned
Modafinil — full profile
Modafinil
Centrally acting sympathomimetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
39
abandoned
Moexipril Hydrochloride — full profile
Moexipril Hydrochloride
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
27
abandoned
Mometasone Furoate — full profile
Mometasone Furoate
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
40
abandoned
Montelukast Sodium — full profile
Montelukast Sodium
Leukotriene receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.1M
people
63
abandoned
Morphine Sulfate — full profile
Morphine Sulfate
Natural opium alkaloids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
32
abandoned
Moxifloxacin Hydrochloride — full profile
Moxifloxacin Hydrochloride
Fluoroquinolones
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Mupirocin — full profile
Mupirocin
Other antibiotics for topical use
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
47
abandoned
Mupirocin Calcium — full profile
Mupirocin Calcium
Other antibiotics for topical use
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Mycophenolate Mofetil — full profile
Mycophenolate Mofetil
Class not recorded
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
17
abandoned
Mycophenolate Mofetil Hydrochloride — full profile
Mycophenolate Mofetil Hydrochloride
Class not recorded
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
44
abandoned
Mycophenolate Sodium — full profile
Mycophenolate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nabumetone — full profile
Nabumetone
Other antiinflammatory and antirheumatic agents, non-steroids
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
48
abandoned
Nadolol — full profile
Nadolol
Beta blocking agents, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
55
abandoned
Nafcillin Sodium — full profile
Nafcillin Sodium
Beta-lactamase resistant penicillins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
34
abandoned
Naftifine Hydrochloride — full profile
Naftifine Hydrochloride
Other antifungals for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.3M
people
0
abandoned
Nalbuphine Hydrochloride — full profile
Nalbuphine Hydrochloride
Morphinan derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
23.3M
people
9
abandoned
Nalmefene Hydrochloride — full profile
Nalmefene Hydrochloride
Drugs used in alcohol dependence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
23.3M
people
0
abandoned
Naloxone Hydrochloride — full profile
Naloxone Hydrochloride
Other opioids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
32
abandoned
Naloxone Hydrochloride; Pentazocine Hydrochloride — full profile
Naloxone Hydrochloride; Pentazocine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.