The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 10411080 of 1,208 generic medicines
Riociguat — full profile
Riociguat
Antihypertensives for pulmonary arterial hypertension
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Risedronate Sodium — full profile
Risedronate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ritonavir — full profile
Ritonavir
Antivirals for treatment of HCV infections
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.7M
people
35
abandoned
Rivaroxaban — full profile
Rivaroxaban
Direct factor Xa inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.4M
people
17
abandoned
Rivastigmine — full profile
Rivastigmine
Anticholinesterases
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.0M
people
34
abandoned
Rivastigmine Tartrate — full profile
Rivastigmine Tartrate
Anticholinesterases
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.0M
people
48
abandoned
Rizatriptan Benzoate — full profile
Rizatriptan Benzoate
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
44
abandoned
Rocuronium Bromide — full profile
Rocuronium Bromide
Other quaternary ammonium compounds
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.6M
people
25
abandoned
Roflumilast — full profile
Roflumilast
Other antipsoriatics for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.9M
people
21
abandoned
Romidepsin — full profile
Romidepsin
Histone deacetylase (HDAC) inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.7M
people
0
abandoned
Ropinirole Hydrochloride — full profile
Ropinirole Hydrochloride
Dopamine agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
63
abandoned
Ropivacaine Hydrochloride — full profile
Ropivacaine Hydrochloride
Amides
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.2M
people
17
abandoned
Rosuvastatin Calcium — full profile
Rosuvastatin Calcium
Combinations of various lipid modifying agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.8M
people
63
abandoned
Rufinamide — full profile
Rufinamide
Carboxamide derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Sacubitril; Valsartan — full profile
Sacubitril; Valsartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Safinamide Mesylate — full profile
Safinamide Mesylate
Monoamine oxidase B inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.3M
people
0
abandoned
Sapropterin Dihydrochloride — full profile
Sapropterin Dihydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Saxagliptin Hydrochloride — full profile
Saxagliptin Hydrochloride
Combinations of oral blood glucose lowering drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.0M
people
19
abandoned
Scopolamine — full profile
Scopolamine
Other antiemetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.7M
people
36
abandoned
Selegiline Hydrochloride — full profile
Selegiline Hydrochloride
Monoamine oxidase B inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.3M
people
27
abandoned
Selenious Acid — full profile
Selenious Acid
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Selenium Sulfide — full profile
Selenium Sulfide
Other antifungals for topical use
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Selexipag — full profile
Selexipag
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.8M
people
0
abandoned
Sertraline Hydrochloride — full profile
Sertraline Hydrochloride
Selective serotonin reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
55
abandoned
Sevelamer Carbonate — full profile
Sevelamer Carbonate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sevelamer Hydrochloride — full profile
Sevelamer Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sevoflurane — full profile
Sevoflurane
Halogenated hydrocarbons
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
34
abandoned
Sildenafil Citrate — full profile
Sildenafil Citrate
Drugs used in erectile dysfunction
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.1M
people
32
abandoned
Silodosin — full profile
Silodosin
Alpha-adrenoreceptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.6M
people
55
abandoned
Simvastatin — full profile
Simvastatin
Dipeptidyl peptidase 4 (DPP-4) inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.8M
people
17
abandoned
Sirolimus — full profile
Sirolimus
Mammalian target of rapamycin (mTOR) kinase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.9M
people
32
abandoned
Sitagliptin Phosphate — full profile
Sitagliptin Phosphate
Dipeptidyl peptidase 4 (DPP-4) inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.0M
people
0
abandoned
Sodium Acetate — full profile
Sodium Acetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Benzoate; Sodium Phenylacetate — full profile
Sodium Benzoate; Sodium Phenylacetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Bicarbonate — full profile
Sodium Bicarbonate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Chloride — full profile
Sodium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Ferric Gluconate Complex — full profile
Sodium Ferric Gluconate Complex
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Fluoride F-18 — full profile
Sodium Fluoride F-18
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Iodide I-123 — full profile
Sodium Iodide I-123
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Iodide I-131 — full profile
Sodium Iodide I-131
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.