The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 11611200 of 1,208 generic medicines
Trandolapril — full profile
Trandolapril
ACE inhibitors and calcium channel blockers
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
19
abandoned
Trandolapril; Verapamil Hydrochloride — full profile
Trandolapril; Verapamil Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Tranexamic Acid — full profile
Tranexamic Acid
Amino acids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.0M
people
63
abandoned
Tranylcypromine Sulfate — full profile
Tranylcypromine Sulfate
Monoamine oxidase inhibitors, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.3M
people
19
abandoned
Travoprost — full profile
Travoprost
Prostaglandin analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.7M
people
6
abandoned
Treprostinil — full profile
Treprostinil
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.8M
people
0
abandoned
Tretinoin — full profile
Tretinoin
Retinoids for topical use in acne
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.9M
people
25
abandoned
Triamcinolone Acetonide — full profile
Triamcinolone Acetonide
Corticosteroids for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
48
abandoned
Triamterene — full profile
Triamterene
Other potassium-sparing agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.2M
people
16
abandoned
Trientine Hydrochloride — full profile
Trientine Hydrochloride
Various alimentary tract and metabolism products
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.3M
people
44
abandoned
Trifluoperazine Hydrochloride — full profile
Trifluoperazine Hydrochloride
Phenothiazines with piperazine structure
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
9
abandoned
Trifluridine — full profile
Trifluridine
Antivirals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Trihexyphenidyl Hydrochloride — full profile
Trihexyphenidyl Hydrochloride
Tertiary amines
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.7M
people
34
abandoned
Trimethobenzamide Hydrochloride — full profile
Trimethobenzamide Hydrochloride
Aminoalkyl ethers
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Tromethamine — full profile
Tromethamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Tropicamide — full profile
Tropicamide
Anticholinergics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
31
abandoned
Trospium Chloride — full profile
Trospium Chloride
Drugs for urinary frequency and incontinence
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Ulipristal Acetate — full profile
Ulipristal Acetate
Emergency contraceptives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.5M
people
0
abandoned
Ursodiol — full profile
Ursodiol
Bile acids and derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Valacyclovir Hydrochloride — full profile
Valacyclovir Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Valbenazine Tosylate — full profile
Valbenazine Tosylate
Other nervous system drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.9M
people
0
abandoned
Valganciclovir Hydrochloride — full profile
Valganciclovir Hydrochloride
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Valproate Sodium — full profile
Valproate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Valproic Acid — full profile
Valproic Acid
Fatty acid derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
39
abandoned
Valrubicin — full profile
Valrubicin
Anthracyclines and related substances
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
2
abandoned
Valsartan — full profile
Valsartan
Angiotensin II receptor blockers (ARBs), other combinations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Vancomycin Hydrochloride — full profile
Vancomycin Hydrochloride
Antibiotics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
32
abandoned
Vardenafil Hydrochloride — full profile
Vardenafil Hydrochloride
Drugs used in erectile dysfunction
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.1M
people
41
abandoned
Varenicline Tartrate — full profile
Varenicline Tartrate
Drugs used in nicotine dependence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.6M
people
17
abandoned
Vasopressin — full profile
Vasopressin
Class not recorded
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.2M
people
25
abandoned
Vecuronium Bromide — full profile
Vecuronium Bromide
Other quaternary ammonium compounds
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.6M
people
59
abandoned
Venetoclax — full profile
Venetoclax
Other antineoplastic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.3M
people
0
abandoned
Verapamil Hydrochloride — full profile
Verapamil Hydrochloride
Phenylalkylamine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
78
abandoned
Vigabatrin — full profile
Vigabatrin
Fatty acid derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
17
abandoned
Vincristine Sulfate — full profile
Vincristine Sulfate
Vinca alkaloids and analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
2
abandoned
Vinorelbine Tartrate — full profile
Vinorelbine Tartrate
Vinca alkaloids and analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Voriconazole — full profile
Voriconazole
Triazole and tetrazole derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.7M
people
63
abandoned
Warfarin Sodium — full profile
Warfarin Sodium
Vitamin K antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.2M
people
39
abandoned
Zafirlukast — full profile
Zafirlukast
Leukotriene receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.1M
people
35
abandoned
Zaleplon — full profile
Zaleplon
Benzodiazepine related drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.5M
people
34
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.