Lonafarnib

Sold as ZOKINVY · given by oral

One to three years until it comes off patent
2.9 yr
Until anyone may copy it
Protection runs to 2029-07-26
3
Trials running now
39 registered in total
Phase 3
Furthest stage reached
large trials measuring benefit
3
Organisations running trials
lead sponsors on record
01

Who owns it, and until when

Sentynl Therapeutics Inc
Approval holder
the only company permitted to sell it today
2029-07
Last patent expires
latest patent filed against this product
2027-11
FDA exclusivity ends
a separate protection granted at approval

Whichever date falls later is when other manufacturers may apply to sell copies. Price typically falls steeply within a year of that point, and with it any company's ability to recover the cost of new research on the molecule. That is when it becomes a candidate for the ledger on the first tab.

02

What it is being tested for

ProgeriaBreast CancerHepatitis D
03

Who is paying for the research

M.D. Anderson Cancer Center
University or hospital
7
Eiger BioPharmaceuticals
Company
6
Merck Sharp & Dohme LLC
Company
5

Who funds the trials matters after protection lapses. Company-funded work usually stops once exclusivity ends; university, hospital and government-funded work does not, and is the research most likely to continue on this molecule afterwards.

04

The trials themselves

NCT06775041Phase 22025 · 10 people · running, closed to new patients
Study to Determine Optimal Dose and Evaluate

Expiry dates are what the patent holder has filed; litigation, paediatric extensions and settlements routinely move them, so read these as the earliest plausible date rather than a schedule. Not medical advice.

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