The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 361400 of 1,208 generic medicines
Cidofovir — full profile
Cidofovir
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Cilastatin Sodium; Imipenem — full profile
Cilastatin Sodium; Imipenem
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cilostazol — full profile
Cilostazol
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.0M
people
34
abandoned
Cimetidine — full profile
Cimetidine
H2-receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.7M
people
54
abandoned
Cimetidine Hydrochloride — full profile
Cimetidine Hydrochloride
H2-receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.7M
people
9
abandoned
Cinacalcet Hydrochloride — full profile
Cinacalcet Hydrochloride
Other anti-parathyroid agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.3M
people
52
abandoned
Ciprofloxacin Hydrochloride; Hydrocortisone — full profile
Ciprofloxacin Hydrochloride; Hydrocortisone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ciprofloxacin; Ciprofloxacin Hydrochloride — full profile
Ciprofloxacin; Ciprofloxacin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ciprofloxacin; Dexamethasone — full profile
Ciprofloxacin; Dexamethasone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cisatracurium Besylate — full profile
Cisatracurium Besylate
Other quaternary ammonium compounds
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.6M
people
70
abandoned
Cisplatin — full profile
Cisplatin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Citalopram Hydrobromide — full profile
Citalopram Hydrobromide
Selective serotonin reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
14
abandoned
Citric Acid; Magnesium Oxide; Sodium Picosulfate — full profile
Citric Acid; Magnesium Oxide; Sodium Picosulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cladribine — full profile
Cladribine
Purine analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.9M
people
11
abandoned
Clarithromycin — full profile
Clarithromycin
Macrolides
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.1M
people
70
abandoned
Clemastine Fumarate — full profile
Clemastine Fumarate
Antihistamines for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
9
abandoned
Clindamycin Hydrochloride — full profile
Clindamycin Hydrochloride
Antiinfectives for treatment of acne
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
51
abandoned
Clindamycin Palmitate Hydrochloride — full profile
Clindamycin Palmitate Hydrochloride
Antiinfectives for treatment of acne
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Clindamycin Phosphate — full profile
Clindamycin Phosphate
Antiinfectives for treatment of acne
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Clindamycin Phosphate; Tretinoin — full profile
Clindamycin Phosphate; Tretinoin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Clobazam — full profile
Clobazam
Benzodiazepine derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
17
abandoned
Clobetasol Propionate — full profile
Clobetasol Propionate
Corticosteroids, very potent (group IV)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
17
abandoned
Clocortolone Pivalate — full profile
Clocortolone Pivalate
Corticosteroids, moderately potent (group II)
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Clomiphene Citrate — full profile
Clomiphene Citrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Clonazepam — full profile
Clonazepam
Benzodiazepine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.0M
people
55
abandoned
Clonidine — full profile
Clonidine
Imidazoline receptor agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.5M
people
0
abandoned
Clonidine Hydrochloride — full profile
Clonidine Hydrochloride
Imidazoline receptor agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.5M
people
32
abandoned
Clopidogrel Bisulfate — full profile
Clopidogrel Bisulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Clorazepate Dipotassium — full profile
Clorazepate Dipotassium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Codeine Phosphate; Phenylephrine Hydrochloride; Promethazine Hydrochloride — full profile
Codeine Phosphate; Phenylephrine Hydrochloride; Promethazine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Codeine Phosphate; Promethazine Hydrochloride — full profile
Codeine Phosphate; Promethazine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Codeine Phosphate; Pseudoephedrine Hydrochloride; Triprolidine Hydrochloride — full profile
Codeine Phosphate; Pseudoephedrine Hydrochloride; Triprolidine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Codeine Sulfate — full profile
Codeine Sulfate
Opioids in combination with non-opioid analgesics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
0
abandoned
Colchicine; Probenecid — full profile
Colchicine; Probenecid
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Colesevelam Hydrochloride — full profile
Colesevelam Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Colestipol Hydrochloride — full profile
Colestipol Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Colistimethate Sodium — full profile
Colistimethate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cosyntropin — full profile
Cosyntropin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cromolyn Sodium — full profile
Cromolyn Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Crotamiton — full profile
Crotamiton
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.