The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 321360 of 1,208 generic medicines
Carvedilol — full profile
Carvedilol
Alpha and beta blocking agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
55
abandoned
Carvedilol Phosphate — full profile
Carvedilol Phosphate
Alpha and beta blocking agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
16
abandoned
Caspofungin Acetate — full profile
Caspofungin Acetate
Other antimycotics for systemic use
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cefaclor — full profile
Cefaclor
Second-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
24
abandoned
Cefadroxil/Cefadroxil Hemihydrate — full profile
Cefadroxil/Cefadroxil Hemihydrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cefazolin Sodium — full profile
Cefazolin Sodium
First-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Cefdinir — full profile
Cefdinir
Third-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
47
abandoned
Cefepime Hydrochloride — full profile
Cefepime Hydrochloride
Fourth-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Cefixime — full profile
Cefixime
Third-generation cephalosporins
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
6.0M
people
3
abandoned
Cefotetan Disodium — full profile
Cefotetan Disodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cefoxitin Sodium — full profile
Cefoxitin Sodium
Second-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Cefpodoxime Proxetil — full profile
Cefpodoxime Proxetil
Third-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Cefprozil — full profile
Cefprozil
Second-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Ceftaroline Fosamil — full profile
Ceftaroline Fosamil
Other cephalosporins and penems
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ceftazidime — full profile
Ceftazidime
Third-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
24
abandoned
Ceftriaxone Sodium — full profile
Ceftriaxone Sodium
Third-generation cephalosporins
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
66K
people
70
abandoned
Cefuroxime Axetil — full profile
Cefuroxime Axetil
Second-generation cephalosporins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Cefuroxime Sodium — full profile
Cefuroxime Sodium
Second-generation cephalosporins
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.5M
people
16
abandoned
Celecoxib — full profile
Celecoxib
Other antineoplastic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.0M
people
17
abandoned
Cephalexin — full profile
Cephalexin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cetirizine Hydrochloride — full profile
Cetirizine Hydrochloride
Piperazine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
40
abandoned
Cetirizine Hydrochloride; Pseudoephedrine Hydrochloride — full profile
Cetirizine Hydrochloride; Pseudoephedrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cetrorelix Acetate — full profile
Cetrorelix Acetate
Anti-gonadotropin-releasing hormones
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.5M
people
41
abandoned
Cevimeline Hydrochloride — full profile
Cevimeline Hydrochloride
Other parasympathomimetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.8M
people
48
abandoned
Chenodiol — full profile
Chenodiol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Chlordiazepoxide Hydrochloride — full profile
Chlordiazepoxide Hydrochloride
Benzodiazepine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.5M
people
19
abandoned
Chlordiazepoxide Hydrochloride; Clidinium Bromide — full profile
Chlordiazepoxide Hydrochloride; Clidinium Bromide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Chlorhexidine Gluconate — full profile
Chlorhexidine Gluconate
Antiinfectives and antiseptics for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.4M
people
29
abandoned
Chloroprocaine Hydrochloride — full profile
Chloroprocaine Hydrochloride
Esters of aminobenzoic acid
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Chlorothiazide Sodium — full profile
Chlorothiazide Sodium
Thiazides, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.8M
people
41
abandoned
Chlorpheniramine Maleate — full profile
Chlorpheniramine Maleate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Chlorpheniramine Polistirex; Hydrocodone Polistirex — full profile
Chlorpheniramine Polistirex; Hydrocodone Polistirex
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Chlorpromazine Hydrochloride — full profile
Chlorpromazine Hydrochloride
Phenothiazines with aliphatic side-chain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
63
abandoned
Chlorthalidone — full profile
Chlorthalidone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Chlorzoxazone — full profile
Chlorzoxazone
Oxazol, thiazine, and triazine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.7M
people
55
abandoned
Cholestyramine — full profile
Cholestyramine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Choline C-11 — full profile
Choline C-11
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Choline Fenofibrate — full profile
Choline Fenofibrate
Fibrates
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
56
abandoned
Chromic Chloride — full profile
Chromic Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ciclopirox — full profile
Ciclopirox
Other antifungals for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.3M
people
55
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.