The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 681720 of 1,208 generic medicines
Hydrochlorothiazide; Metoprolol Tartrate — full profile
Hydrochlorothiazide; Metoprolol Tartrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Moexipril Hydrochloride — full profile
Hydrochlorothiazide; Moexipril Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Olmesartan Medoxomil — full profile
Hydrochlorothiazide; Olmesartan Medoxomil
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Quinapril Hydrochloride — full profile
Hydrochlorothiazide; Quinapril Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Spironolactone — full profile
Hydrochlorothiazide; Spironolactone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Telmisartan — full profile
Hydrochlorothiazide; Telmisartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Triamterene — full profile
Hydrochlorothiazide; Triamterene
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Valsartan — full profile
Hydrochlorothiazide; Valsartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrocodone Bitartrate — full profile
Hydrocodone Bitartrate
Opioids in combination with non-opioid analgesics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
0
abandoned
Hydrocodone Bitartrate; Ibuprofen — full profile
Hydrocodone Bitartrate; Ibuprofen
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrocortisone — full profile
Hydrocortisone
Corticosteroids, moderately potent (group II)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
25
abandoned
Hydrocortisone Acetate — full profile
Hydrocortisone Acetate
Corticosteroids, moderately potent (group II)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
0
abandoned
Hydrocortisone Acetate; Pramoxine Hydrochloride — full profile
Hydrocortisone Acetate; Pramoxine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrocortisone Butyrate — full profile
Hydrocortisone Butyrate
Corticosteroids, moderately potent (group II)
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Hydrocortisone Sodium Succinate — full profile
Hydrocortisone Sodium Succinate
Corticosteroids, moderately potent (group II)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
27
abandoned
Hydrocortisone Valerate — full profile
Hydrocortisone Valerate
Corticosteroids for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
27
abandoned
Hydrocortisone; Neomycin Sulfate; Polymyxin B Sulfate — full profile
Hydrocortisone; Neomycin Sulfate; Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydromorphone Hydrochloride — full profile
Hydromorphone Hydrochloride
Natural opium alkaloids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
25
abandoned
Hydroxocobalamin — full profile
Hydroxocobalamin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydroxychloroquine Sulfate — full profile
Hydroxychloroquine Sulfate
Aminoquinolines
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.0M
people
55
abandoned
Hydroxyurea — full profile
Hydroxyurea
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydroxyzine Hydrochloride — full profile
Hydroxyzine Hydrochloride
Diphenylmethane derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
63
abandoned
Hydroxyzine Pamoate — full profile
Hydroxyzine Pamoate
Diphenylmethane derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
34
abandoned
Ibandronate Sodium — full profile
Ibandronate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ibuprofen — full profile
Ibuprofen
Opioids in combination with non-opioid analgesics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
40
abandoned
Ibuprofen Lysine — full profile
Ibuprofen Lysine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ibuprofen; Phenylephrine Hydrochloride — full profile
Ibuprofen; Phenylephrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ibuprofen; Pseudoephedrine Hydrochloride — full profile
Ibuprofen; Pseudoephedrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ibutilide Fumarate — full profile
Ibutilide Fumarate
Antiarrhythmics, class III
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.1M
people
9
abandoned
Icatibant Acetate — full profile
Icatibant Acetate
Drugs used in hereditary angioedema
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
1.7M
people
56
abandoned
Icosapent Ethyl — full profile
Icosapent Ethyl
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
17
abandoned
Idarubicin Hydrochloride — full profile
Idarubicin Hydrochloride
Anthracyclines and related substances
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Idelalisib — full profile
Idelalisib
Phosphatidylinositol-3-kinase (Pi3K) inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.6M
people
0
abandoned
Ifosfamide — full profile
Ifosfamide
Nitrogen mustard analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
19
abandoned
Iloprost — full profile
Iloprost
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.8M
people
0
abandoned
Imiquimod — full profile
Imiquimod
Antivirals
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.4M
people
0
abandoned
Inamrinone Lactate — full profile
Inamrinone Lactate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Indapamide — full profile
Indapamide
Sulfonamides, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.8M
people
19
abandoned
Indium In-111 Oxyquinoline — full profile
Indium In-111 Oxyquinoline
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Indocyanine Green — full profile
Indocyanine Green
Other diagnostic agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.