The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 721760 of 1,208 generic medicines
Indomethacin — full profile
Indomethacin
Other cardiac preparations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
70
abandoned
Iodixanol — full profile
Iodixanol
Watersoluble, nephrotropic, low osmolar X-ray contrast media
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
10
abandoned
Ioflupane I-123 — full profile
Ioflupane I-123
Iodine (123I) compounds
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Iohexol — full profile
Iohexol
Watersoluble, nephrotropic, low osmolar X-ray contrast media
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
10
abandoned
Iopamidol — full profile
Iopamidol
Watersoluble, nephrotropic, low osmolar X-ray contrast media
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ipratropium Bromide — full profile
Ipratropium Bromide
Other nasal preparations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
17
abandoned
Irbesartan — full profile
Irbesartan
Angiotensin II receptor blockers (ARBs), plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.6M
people
63
abandoned
Irinotecan Hydrochloride — full profile
Irinotecan Hydrochloride
Topoisomerase 1 (TOP1) inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Iron Sucrose — full profile
Iron Sucrose
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Isoflurane — full profile
Isoflurane
Halogenated hydrocarbons
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Isoniazid — full profile
Isoniazid
Combinations of drugs for treatment of tuberculosis
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.4M
people
41
abandoned
Isoproterenol Hydrochloride — full profile
Isoproterenol Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Isosorbide Dinitrate — full profile
Isosorbide Dinitrate
Organic nitrates
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Isosorbide Mononitrate — full profile
Isosorbide Mononitrate
Organic nitrates
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
67
abandoned
Isosulfan Blue — full profile
Isosulfan Blue
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Isotretinoin — full profile
Isotretinoin
Retinoids for topical use in acne
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
10
abandoned
Ivabradine Hydrochloride — full profile
Ivabradine Hydrochloride
Other cardiac preparations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.8M
people
39
abandoned
Ivermectin — full profile
Ivermectin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ketamine Hydrochloride — full profile
Ketamine Hydrochloride
Other general anesthetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.7M
people
39
abandoned
Ketoconazole — full profile
Ketoconazole
Anticorticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.4M
people
78
abandoned
Ketoprofen — full profile
Ketoprofen
Propionic acid derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
27
abandoned
Ketorolac Tromethamine — full profile
Ketorolac Tromethamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ketorolac Tromethamine; Phenylephrine Hydrochloride — full profile
Ketorolac Tromethamine; Phenylephrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ketotifen Fumarate — full profile
Ketotifen Fumarate
Other antihistamines for systemic use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
27
abandoned
L-Glutamine — full profile
L-Glutamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Labetalol Hydrochloride — full profile
Labetalol Hydrochloride
Alpha and beta blocking agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
63
abandoned
Lacosamide — full profile
Lacosamide
Other antiepileptics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.1M
people
32
abandoned
Lactulose — full profile
Lactulose
Osmotically acting laxatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Lamivudine — full profile
Lamivudine
Antivirals for treatment of HIV infections, combinations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Lamivudine; Zidovudine — full profile
Lamivudine; Zidovudine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lanreotide Acetate — full profile
Lanreotide Acetate
Somatostatin and analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.3M
people
2
abandoned
Lansoprazole — full profile
Lansoprazole
Proton pump inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
40
abandoned
Lanthanum Carbonate — full profile
Lanthanum Carbonate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lapatinib Ditosylate — full profile
Lapatinib Ditosylate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Latanoprost — full profile
Latanoprost
Prostaglandin analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.7M
people
0
abandoned
Latanoprostene Bunod — full profile
Latanoprostene Bunod
Prostaglandin analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.7M
people
0
abandoned
Leflunomide — full profile
Leflunomide
Dihydroorotate dehydrogenase (DHODH) inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
52
abandoned
Lenalidomide — full profile
Lenalidomide
Other immunosuppressants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
6.7M
people
25
abandoned
Letrozole — full profile
Letrozole
Aromatase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
34
abandoned
Leuprolide Acetate — full profile
Leuprolide Acetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.