The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 761800 of 1,208 generic medicines
Levalbuterol Hydrochloride — full profile
Levalbuterol Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Levetiracetam — full profile
Levetiracetam
Other antiepileptics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.0M
people
32
abandoned
Levobunolol Hydrochloride — full profile
Levobunolol Hydrochloride
Beta blocking agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
0
abandoned
Levocarnitine — full profile
Levocarnitine
Amino acids and derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
51
abandoned
Levocetirizine Dihydrochloride — full profile
Levocetirizine Dihydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Levofloxacin — full profile
Levofloxacin
Fluoroquinolones
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
404K
people
63
abandoned
Levoleucovorin Calcium — full profile
Levoleucovorin Calcium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Levonorgestrel — full profile
Levonorgestrel
Progestogens and estrogens, fixed combinations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.5M
people
32
abandoned
Levorphanol Tartrate — full profile
Levorphanol Tartrate
Class not recorded
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
34
abandoned
Levothyroxine Sodium — full profile
Levothyroxine Sodium
Thyroid hormones
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.1M
people
32
abandoned
Lidocaine; Prilocaine — full profile
Lidocaine; Prilocaine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Linagliptin — full profile
Linagliptin
Dipeptidyl peptidase 4 (DPP-4) inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.0M
people
18
abandoned
Linagliptin; Metformin Hydrochloride — full profile
Linagliptin; Metformin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lincomycin Hydrochloride — full profile
Lincomycin Hydrochloride
Lincosamides
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Linezolid — full profile
Linezolid
Other antibacterials
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.4M
people
63
abandoned
Liothyronine Sodium — full profile
Liothyronine Sodium
Thyroid hormones
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.1M
people
59
abandoned
Liraglutide — full profile
Liraglutide
Insulins and analogues for injection, long-acting
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.4M
people
21
abandoned
Lisdexamfetamine Dimesylate — full profile
Lisdexamfetamine Dimesylate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lisinopril — full profile
Lisinopril
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
25
abandoned
Lithium Carbonate — full profile
Lithium Carbonate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lithium Citrate — full profile
Lithium Citrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lofexidine Hydrochloride — full profile
Lofexidine Hydrochloride
Drugs used in opioid dependence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
19
abandoned
Lomustine — full profile
Lomustine
Nitrosoureas
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Loperamide Hydrochloride — full profile
Loperamide Hydrochloride
Antipropulsives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
78
abandoned
Loperamide Hydrochloride; Simethicone — full profile
Loperamide Hydrochloride; Simethicone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lopinavir; Ritonavir — full profile
Lopinavir; Ritonavir
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Loratadine — full profile
Loratadine
Other antihistamines for systemic use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
70
abandoned
Loratadine; Pseudoephedrine Sulfate — full profile
Loratadine; Pseudoephedrine Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lorazepam — full profile
Lorazepam
Benzodiazepine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.0M
people
32
abandoned
Losartan Potassium — full profile
Losartan Potassium
Angiotensin II receptor blockers (ARBs), plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.6M
people
17
abandoned
Loteprednol Etabonate — full profile
Loteprednol Etabonate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Loteprednol Etabonate; Tobramycin — full profile
Loteprednol Etabonate; Tobramycin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Lovastatin — full profile
Lovastatin
Combinations of various lipid modifying agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.8M
people
44
abandoned
Lubiprostone — full profile
Lubiprostone
Other drugs for constipation
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Macitentan — full profile
Macitentan
Antihypertensives for pulmonary arterial hypertension
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.7M
people
25
abandoned
Magnesium Chloride; Potassium Chloride; Sodium Acetate; Sodium Chloride; Sodium Gluconate — full profile
Magnesium Chloride; Potassium Chloride; Sodium Acetate; Sodium Chloride; Sodium Gluconate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Magnesium Sulfate — full profile
Magnesium Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Magnesium Sulfate; Potassium Chloride; Sodium Sulfate — full profile
Magnesium Sulfate; Potassium Chloride; Sodium Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate — full profile
Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Malathion — full profile
Malathion
Other ectoparasiticides, incl. scabicides
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.