The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 4180 of 1,208 generic medicines
Isradipine — full profile
Isradipine
Dihydropyridine derivatives · could also reach aldosterone-producing adenoma with seizures and neur
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
22.9M
people
9
abandoned
Itraconazole — full profile
Itraconazole
Triazole and tetrazole derivatives · could also reach nephrogenic diabetes insipidus
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
31.8M
people
18
abandoned
Lamotrigine — full profile
Lamotrigine1 WRONG-WAY
Other antiepileptics · could also reach paramyotonia congenita of Von Eulenburg
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
22.1M
people
25
abandoned
Leucovorin Calcium — full profile
Leucovorin Calcium
Detoxifying agents for antineoplastic treatment · could also reach constitutional megaloblastic anemia with severe neur
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.9M
people
32
abandoned
Levomilnacipran Hydrochloride — full profile
Levomilnacipran Hydrochloride
Other antidepressants · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
0
abandoned
Lidocaine — full profile
Lidocaine1 WRONG-WAY
Antiarrhythmics, class Ib · could also reach Brugada syndrome 1
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
27.6M
people
17
abandoned
Lidocaine Hydrochloride — full profile
Lidocaine Hydrochloride1 WRONG-WAY
Antiarrhythmics, class Ib · could also reach Brugada syndrome 1
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
27.6M
people
70
abandoned
Loxapine Succinate — full profile
Loxapine Succinate
Diazepines, oxazepines, thiazepines and oxepines · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
19
abandoned
Lurasidone Hydrochloride — full profile
Lurasidone Hydrochloride
Indole derivatives · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
17
abandoned
Mebendazole — full profile
Mebendazole
Benzimidazole derivatives · could also reach chronic myelogenous leukemia, BCR-ABL1 positive
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
31.4M
people
0
abandoned
Mefloquine Hydrochloride — full profile
Mefloquine Hydrochloride
Methanolquinolines · could also reach Romano-Ward syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
21.6M
people
9
abandoned
Methotrexate Sodium — full profile
Methotrexate Sodium
Folic acid analogues · could also reach constitutional megaloblastic anemia with severe neur
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
15.7M
people
32
abandoned
Methylphenidate — full profile
Methylphenidate
Centrally acting sympathomimetics · could also reach Infantile dystonia-parkinsonism
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
29.3M
people
0
abandoned
Methylphenidate Hydrochloride — full profile
Methylphenidate Hydrochloride
Centrally acting sympathomimetics · could also reach Infantile dystonia-parkinsonism
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
29.3M
people
25
abandoned
Miconazole Nitrate — full profile
Miconazole Nitrate
Antiinfectives and antiseptics for local oral treatment · could also reach congenital adrenal hyperplasia due to 17-alpha-hydro
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
42.7M
people
47
abandoned
Midazolam — full profile
Midazolam
Benzodiazepine derivatives · could also reach developmental and epileptic encephalopathy, 43
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
28.2M
people
0
abandoned
Midazolam Hydrochloride — full profile
Midazolam Hydrochloride
Benzodiazepine derivatives · could also reach developmental and epileptic encephalopathy, 43
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
28.2M
people
56
abandoned
Midostaurin — full profile
Midostaurin
Other protein kinase inhibitors · could also reach acute myeloid leukemia
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
21.5M
people
0
abandoned
Mifepristone — full profile
Mifepristone3 WRONG-WAY
Progesterone receptor modulators · could also reach glucocorticoid resistance
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
30.7M
people
0
abandoned
Milnacipran Hydrochloride — full profile
Milnacipran Hydrochloride
Other antidepressants · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
0
abandoned
Mitoxantrone Hydrochloride — full profile
Mitoxantrone Hydrochloride
Anthracyclines and related substances · could also reach neoplasm
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
18.0M
people
42
abandoned
Molindone Hydrochloride — full profile
Molindone Hydrochloride
Indole derivatives · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
0
abandoned
Nefazodone Hydrochloride — full profile
Nefazodone Hydrochloride
Other antidepressants · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
47.4M
people
0
abandoned
Nifedipine — full profile
Nifedipine
Beta blocking agents and calcium channel blockers · could also reach aldosterone-producing adenoma with seizures and neur
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
22.9M
people
63
abandoned
Norepinephrine Bitartrate — full profile
Norepinephrine Bitartrate
Adrenergic and dopaminergic agents · could also reach hypertensive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
31.6M
people
17
abandoned
Nortriptyline Hydrochloride — full profile
Nortriptyline Hydrochloride
Non-selective monoamine reuptake inhibitors · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
34
abandoned
Ofloxacin — full profile
Ofloxacin
Fluoroquinolones · could also reach alcohol dependence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
47.9M
people
55
abandoned
Olanzapine — full profile
Olanzapine
Diazepines, oxazepines, thiazepines and oxepines · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
55
abandoned
Orphenadrine Citrate — full profile
Orphenadrine Citrate
Ethers chemically close to antihistamines · could also reach Dravet syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
43.5M
people
59
abandoned
Oxiconazole Nitrate — full profile
Oxiconazole Nitrate
Imidazole and triazole derivatives · could also reach ghosal hematodiaphyseal dysplasia
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
66.1M
people
0
abandoned
Oxymetazoline Hydrochloride — full profile
Oxymetazoline Hydrochloride
Other dermatologicals · could also reach benign prostatic hyperplasia
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
22.5M
people
0
abandoned
Paclitaxel — full profile
Paclitaxel
Taxanes · could also reach multiple benign circumferential skin creases on limb
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
16.7M
people
32
abandoned
Paliperidone — full profile
Paliperidone
Other antipsychotics · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
63
abandoned
Pazopanib Hydrochloride — full profile
Pazopanib Hydrochloride3 WRONG-WAY
Other protein kinase inhibitors · could also reach gastrointestinal stromal tumor
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
56.6M
people
47
abandoned
Phenoxybenzamine Hydrochloride — full profile
Phenoxybenzamine Hydrochloride
Other peripheral vasodilators · could also reach asthma
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
24.1M
people
34
abandoned
Phentolamine Mesylate — full profile
Phentolamine Mesylate2 WRONG-WAY
Imidazoline derivatives · could also reach hypertensive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
24.8M
people
0
abandoned
Phenytoin — full profile
Phenytoin
Hydantoin derivatives · could also reach paramyotonia congenita of Von Eulenburg
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
18.1M
people
27
abandoned
Phenytoin Sodium — full profile
Phenytoin Sodium
Hydantoin derivatives · could also reach paramyotonia congenita of Von Eulenburg
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
18.1M
people
51
abandoned
Pioglitazone Hydrochloride — full profile
Pioglitazone Hydrochloride
Combinations of oral blood glucose lowering drugs · could also reach type 2 diabetes mellitus
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
21.3M
people
55
abandoned
Pralatrexate — full profile
Pralatrexate
Folic acid analogues · could also reach constitutional megaloblastic anemia with severe neur
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
15.7M
people
2
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.