The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 81120 of 1,208 generic medicines
Primaquine Phosphate — full profile
Primaquine Phosphate
Aminoquinolines · could also reach Romano-Ward syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
42.8M
people
9
abandoned
Propafenone Hydrochloride — full profile
Propafenone Hydrochloride3 WRONG-WAY
Antiarrhythmics, class Ic · could also reach Brugada syndrome 1
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
29.5M
people
59
abandoned
Protriptyline Hydrochloride — full profile
Protriptyline Hydrochloride
Non-selective monoamine reuptake inhibitors · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
9
abandoned
Pyrimethamine — full profile
Pyrimethamine
Diaminopyrimidines · could also reach Tay-Sachs disease
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
38.7M
people
19
abandoned
Quetiapine Fumarate — full profile
Quetiapine Fumarate
Diazepines, oxazepines, thiazepines and oxepines · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
63
abandoned
Quinidine Gluconate — full profile
Quinidine Gluconate
Antiarrhythmics, class Ia · could also reach Dravet syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
20.9M
people
16
abandoned
Quinidine Sulfate — full profile
Quinidine Sulfate
Antiarrhythmics, class Ia · could also reach Dravet syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
20.9M
people
0
abandoned
Quinine Sulfate — full profile
Quinine Sulfate
Methanolquinolines · could also reach Dravet syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
20.2M
people
27
abandoned
Raloxifene Hydrochloride — full profile
Raloxifene Hydrochloride
Selective estrogen receptor modulators · could also reach breast cancer
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
20.3M
people
56
abandoned
Risperidone — full profile
Risperidone
Other antipsychotics · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
25
abandoned
Solriamfetol Hydrochloride — full profile
Solriamfetol Hydrochloride
Centrally acting sympathomimetics · could also reach Infantile dystonia-parkinsonism
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
29.3M
people
0
abandoned
Sorafenib Tosylate — full profile
Sorafenib Tosylate
Other protein kinase inhibitors · could also reach gastrointestinal stromal tumor
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
71.5M
people
3
abandoned
Sotalol Hydrochloride — full profile
Sotalol Hydrochloride1 WRONG-WAY
Beta blocking agents, non-selective · could also reach Romano-Ward syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
23.3M
people
13
abandoned
Sulfacetamide Sodium — full profile
Sulfacetamide Sodium
Antiinfectives for treatment of acne · could also reach constitutional megaloblastic anemia with severe neur
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
15.7M
people
27
abandoned
Sunitinib Malate — full profile
Sunitinib Malate1 WRONG-WAY
Other protein kinase inhibitors · could also reach gastrointestinal stromal tumor
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
56.2M
people
48
abandoned
Tamsulosin Hydrochloride — full profile
Tamsulosin Hydrochloride
Alpha-adrenoreceptor antagonists · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
49.3M
people
55
abandoned
Tapentadol Hydrochloride — full profile
Tapentadol Hydrochloride
Other opioids · could also reach opiate dependence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
37.7M
people
0
abandoned
Terbinafine Hydrochloride — full profile
Terbinafine Hydrochloride
Other antifungals for topical use · could also reach autosomal recessive distal spinal muscular atrophy 2
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
35.3M
people
71
abandoned
Terconazole — full profile
Terconazole
Triazole derivatives · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
51.0M
people
19
abandoned
Tetracaine Hydrochloride — full profile
Tetracaine Hydrochloride
Local anesthetics · could also reach Dravet syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
25.0M
people
0
abandoned
Tofacitinib Citrate — full profile
Tofacitinib Citrate
Janus-associated kinase (JAK) inhibitors · could also reach acquired polycythemia vera
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
29.6M
people
25
abandoned
Trazodone Hydrochloride — full profile
Trazodone Hydrochloride
Other antidepressants · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
41.0M
people
17
abandoned
Triazolam — full profile
Triazolam
Benzodiazepine derivatives · could also reach childhood absence epilepsy
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
26.4M
people
9
abandoned
Trimethoprim — full profile
Trimethoprim
Combinations of sulfonamides and trimethoprim, incl. derivatives · could also reach constitutional megaloblastic anemia with severe neur
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
15.7M
people
19
abandoned
Trimipramine Maleate — full profile
Trimipramine Maleate3 WRONG-WAY
Non-selective monoamine reuptake inhibitors · could also reach Infantile dystonia-parkinsonism
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
39.6M
people
9
abandoned
Venlafaxine Hydrochloride — full profile
Venlafaxine Hydrochloride
Other antidepressants · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
63
abandoned
Vilazodone Hydrochloride — full profile
Vilazodone Hydrochloride
Other antidepressants · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
33.8M
people
41
abandoned
Vinblastine Sulfate — full profile
Vinblastine Sulfate
Vinca alkaloids and analogues · could also reach multiple benign circumferential skin creases on limb
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
16.7M
people
16
abandoned
Ziprasidone Hydrochloride — full profile
Ziprasidone Hydrochloride
Indole derivatives · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
44
abandoned
Ziprasidone Mesylate — full profile
Ziprasidone Mesylate
Indole derivatives · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
11
abandoned
Abacavir Sulfate — full profile
Abacavir Sulfate
Antivirals for treatment of HIV infections, combinations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
34
abandoned
Abacavir Sulfate; Lamivudine — full profile
Abacavir Sulfate; Lamivudine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Abiraterone Acetate — full profile
Abiraterone Acetate
Other hormone antagonists and related agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.4M
people
17
abandoned
Acamprosate Calcium — full profile
Acamprosate Calcium
Drugs used in alcohol dependence
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Acarbose — full profile
Acarbose
Alpha glucosidase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
1.8M
people
41
abandoned
Acebutolol Hydrochloride — full profile
Acebutolol Hydrochloride
Beta blocking agents, selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
9
abandoned
Acetaminophen — full profile
Acetaminophen
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Aspirin; Caffeine — full profile
Acetaminophen; Aspirin; Caffeine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Butalbital — full profile
Acetaminophen; Butalbital
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Butalbital; Caffeine — full profile
Acetaminophen; Butalbital; Caffeine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.