The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 921960 of 1,208 generic medicines
Omeprazole — full profile
Omeprazole
Combinations for eradication of Helicobacter pylori
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.9M
people
40
abandoned
Omeprazole Magnesium — full profile
Omeprazole Magnesium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Omeprazole; Sodium Bicarbonate — full profile
Omeprazole; Sodium Bicarbonate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ondansetron — full profile
Ondansetron
Serotonin (5HT3) antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.4M
people
39
abandoned
Ondansetron Hydrochloride — full profile
Ondansetron Hydrochloride
Serotonin (5HT3) antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.4M
people
63
abandoned
Oseltamivir Phosphate — full profile
Oseltamivir Phosphate
Neuraminidase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Oxacillin Sodium — full profile
Oxacillin Sodium
Beta-lactamase resistant penicillins
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.2M
people
34
abandoned
Oxaliplatin — full profile
Oxaliplatin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Oxaprozin — full profile
Oxaprozin
Propionic acid derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
27
abandoned
Oxazepam — full profile
Oxazepam
Benzodiazepine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.0M
people
27
abandoned
Oxcarbazepine — full profile
Oxcarbazepine
Carboxamide derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Oxybutynin Chloride — full profile
Oxybutynin Chloride
Drugs for urinary frequency and incontinence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.8M
people
63
abandoned
Oxycodone Hydrochloride — full profile
Oxycodone Hydrochloride
Natural opium alkaloids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
25
abandoned
Oxymorphone Hydrochloride — full profile
Oxymorphone Hydrochloride
Natural opium alkaloids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
23.3M
people
51
abandoned
Oxytocin — full profile
Oxytocin
Oxytocin and analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.3M
people
24
abandoned
Palonosetron Hydrochloride — full profile
Palonosetron Hydrochloride
Serotonin (5HT3) antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.4M
people
55
abandoned
Pamidronate Disodium — full profile
Pamidronate Disodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Pancuronium Bromide — full profile
Pancuronium Bromide
Other quaternary ammonium compounds
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.6M
people
2
abandoned
Pantoprazole Sodium — full profile
Pantoprazole Sodium
Proton pump inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
32
abandoned
Paricalcitol — full profile
Paricalcitol
Other anti-parathyroid agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.1M
people
59
abandoned
Paromomycin Sulfate — full profile
Paromomycin Sulfate
Antibiotics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
2
abandoned
Paroxetine Hydrochloride — full profile
Paroxetine Hydrochloride
Selective serotonin reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
63
abandoned
Paroxetine Mesylate — full profile
Paroxetine Mesylate
Selective serotonin reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
0
abandoned
Pemetrexed Disodium — full profile
Pemetrexed Disodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Penciclovir — full profile
Penciclovir
Antivirals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Penicillamine — full profile
Penicillamine
Penicillamine and similar agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
48
abandoned
Penicillin G Potassium — full profile
Penicillin G Potassium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Penicillin G Procaine — full profile
Penicillin G Procaine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Penicillin G Sodium — full profile
Penicillin G Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Penicillin V Potassium — full profile
Penicillin V Potassium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Pentamidine Isethionate — full profile
Pentamidine Isethionate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Pentobarbital Sodium — full profile
Pentobarbital Sodium
Barbiturates, plain
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Pentostatin — full profile
Pentostatin
Other antineoplastic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.9M
people
2
abandoned
Pentoxifylline — full profile
Pentoxifylline
Purine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.8M
people
27
abandoned
Perampanel — full profile
Perampanel
Other antiepileptics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.7M
people
19
abandoned
Perindopril Erbumine — full profile
Perindopril Erbumine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Permethrin — full profile
Permethrin
Pyrethrines, incl. synthetic compounds
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
49
abandoned
Perphenazine — full profile
Perphenazine
Phenothiazines with piperazine structure
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
52
abandoned
Phendimetrazine Tartrate — full profile
Phendimetrazine Tartrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Phenelzine Sulfate — full profile
Phenelzine Sulfate
Monoamine oxidase inhibitors, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.6M
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.