The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 9611000 of 1,208 generic medicines
Phentermine Hydrochloride — full profile
Phentermine Hydrochloride
Centrally acting antiobesity products
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Phentermine Hydrochloride; Topiramate — full profile
Phentermine Hydrochloride; Topiramate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Phenylephrine Hydrochloride — full profile
Phenylephrine Hydrochloride
Sympathomimetics excl. antiglaucoma preparations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
17
abandoned
Phenylephrine Hydrochloride; Promethazine Hydrochloride — full profile
Phenylephrine Hydrochloride; Promethazine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Phytonadione — full profile
Phytonadione
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Pilocarpine Hydrochloride — full profile
Pilocarpine Hydrochloride
Other parasympathomimetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
6
abandoned
Pimecrolimus — full profile
Pimecrolimus
Agents for dermatitis, excluding corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.9M
people
16
abandoned
Pimozide — full profile
Pimozide
Diphenylbutylpiperidine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
0
abandoned
Pindolol — full profile
Pindolol
Beta blocking agents, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
34
abandoned
Piperacillin Sodium — full profile
Piperacillin Sodium
Penicillins with extended spectrum
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
2
abandoned
Piperacillin Sodium; Tazobactam Sodium — full profile
Piperacillin Sodium; Tazobactam Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Pirfenidone — full profile
Pirfenidone
Other immunosuppressants
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
17
abandoned
Piroxicam — full profile
Piroxicam
Oxicams
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
34
abandoned
Pitavastatin Calcium — full profile
Pitavastatin Calcium
HMG CoA reductase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.8M
people
56
abandoned
Pitolisant Hydrochloride — full profile
Pitolisant Hydrochloride
Other nervous system drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.2M
people
0
abandoned
Plerixafor — full profile
Plerixafor
Other immunostimulants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.5M
people
44
abandoned
Podofilox — full profile
Podofilox
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Polyethylene Glycol 3350 — full profile
Polyethylene Glycol 3350
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Polyethylene Glycol 3350; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride — full profile
Polyethylene Glycol 3350; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Polyethylene Glycol 3350; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride; Sodium Sulfate Anhydrous — full profile
Polyethylene Glycol 3350; Potassium Chloride; Sodium Bicarbonate; Sodium Chloride; Sodium Sulfate Anhydrous
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Polymyxin B Sulfate — full profile
Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Polymyxin B Sulfate; Trimethoprim Sulfate — full profile
Polymyxin B Sulfate; Trimethoprim Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Pomalidomide — full profile
Pomalidomide
Other immunosuppressants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
6.7M
people
3
abandoned
Posaconazole — full profile
Posaconazole
Triazole and tetrazole derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
40
abandoned
Potassium Acetate — full profile
Potassium Acetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Potassium Chloride — full profile
Potassium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Potassium Chloride; Sodium Chloride — full profile
Potassium Chloride; Sodium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Potassium Citrate — full profile
Potassium Citrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Potassium Iodide — full profile
Potassium Iodide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Potassium Phosphate, Dibasic; Potassium Phosphate, Monobasic — full profile
Potassium Phosphate, Dibasic; Potassium Phosphate, Monobasic
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Pramipexole Dihydrochloride — full profile
Pramipexole Dihydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Prasugrel Hydrochloride — full profile
Prasugrel Hydrochloride
Platelet aggregation inhibitors excl. heparin
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
39
abandoned
Pravastatin Sodium — full profile
Pravastatin Sodium
HMG CoA reductase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.8M
people
63
abandoned
Praziquantel — full profile
Praziquantel
Quinoline derivatives and related substances
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Prazosin Hydrochloride — full profile
Prazosin Hydrochloride
Alpha-adrenoreceptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
52
abandoned
Prednicarbate — full profile
Prednicarbate
Corticosteroids, potent (group III)
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Prednisolone — full profile
Prednisolone
Corticosteroids for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
52
abandoned
Prednisolone Acetate — full profile
Prednisolone Acetate
Corticosteroids for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
1
abandoned
Prednisolone Sodium Phosphate — full profile
Prednisolone Sodium Phosphate
Corticosteroids for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
39
abandoned
Prednisolone Sodium Phosphate; Sulfacetamide Sodium — full profile
Prednisolone Sodium Phosphate; Sulfacetamide Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.