The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 161200 of 1,208 generic medicines
Amiloride Hydrochloride; Hydrochlorothiazide — full profile
Amiloride Hydrochloride; Hydrochlorothiazide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amino Acids — full profile
Amino Acids
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Aminocaproic Acid — full profile
Aminocaproic Acid
Amino acids
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Aminophylline — full profile
Aminophylline
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Aminosalicylic Acid — full profile
Aminosalicylic Acid
Aminosalicylic acid and derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
2
abandoned
Amiodarone Hydrochloride — full profile
Amiodarone Hydrochloride
Antiarrhythmics, class III
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.1M
people
32
abandoned
Amitriptyline Hydrochloride; Chlordiazepoxide — full profile
Amitriptyline Hydrochloride; Chlordiazepoxide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amitriptyline Hydrochloride; Perphenazine — full profile
Amitriptyline Hydrochloride; Perphenazine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amlodipine Besylate — full profile
Amlodipine Besylate
Renin-inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.6M
people
17
abandoned
Amlodipine Besylate; Atorvastatin Calcium — full profile
Amlodipine Besylate; Atorvastatin Calcium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amlodipine Besylate; Benazepril Hydrochloride — full profile
Amlodipine Besylate; Benazepril Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amlodipine Besylate; Hydrochlorothiazide; Olmesartan Medoxomil — full profile
Amlodipine Besylate; Hydrochlorothiazide; Olmesartan Medoxomil
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amlodipine Besylate; Hydrochlorothiazide; Valsartan — full profile
Amlodipine Besylate; Hydrochlorothiazide; Valsartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amlodipine Besylate; Olmesartan Medoxomil — full profile
Amlodipine Besylate; Olmesartan Medoxomil
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amlodipine Besylate; Telmisartan — full profile
Amlodipine Besylate; Telmisartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amlodipine Besylate; Valsartan — full profile
Amlodipine Besylate; Valsartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ammonia N-13 — full profile
Ammonia N-13
Other cardiovascular system diagnostic radiopharmaceuticals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Ammonium Chloride — full profile
Ammonium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ammonium Lactate — full profile
Ammonium Lactate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amoxicillin — full profile
Amoxicillin
Combinations for eradication of Helicobacter pylori
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
56
abandoned
Amoxicillin; Clarithromycin; Lansoprazole — full profile
Amoxicillin; Clarithromycin; Lansoprazole
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amoxicillin; Clavulanate Potassium — full profile
Amoxicillin; Clavulanate Potassium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amphetamine — full profile
Amphetamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amphetamine Aspartate; Amphetamine Sulfate; Dextroamphetamine Saccharate; Dextroamphetamine Sulfate — full profile
Amphetamine Aspartate; Amphetamine Sulfate; Dextroamphetamine Saccharate; Dextroamphetamine Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amphetamine Sulfate — full profile
Amphetamine Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Amphotericin B — full profile
Amphotericin B
Antiinfectives and antiseptics for local oral treatment
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
49
abandoned
Ampicillin Sodium — full profile
Ampicillin Sodium
Combinations of penicillins, incl. beta-lactamase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
725K
people
56
abandoned
Ampicillin Sodium; Sulbactam Sodium — full profile
Ampicillin Sodium; Sulbactam Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ampicillin/Ampicillin Trihydrate — full profile
Ampicillin/Ampicillin Trihydrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Anagrelide Hydrochloride — full profile
Anagrelide Hydrochloride
Other antineoplastic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.0M
people
27
abandoned
Anastrozole — full profile
Anastrozole
Aromatase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
48
abandoned
Angiotensin Ii Acetate — full profile
Angiotensin Ii Acetate
Other cardiac stimulants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.6M
people
0
abandoned
Apalutamide — full profile
Apalutamide
Anti-androgens
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
0
abandoned
Apixaban — full profile
Apixaban
Direct factor Xa inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.4M
people
0
abandoned
Apomorphine Hydrochloride — full profile
Apomorphine Hydrochloride
Drugs used in erectile dysfunction
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
0
abandoned
Apraclonidine Hydrochloride — full profile
Apraclonidine Hydrochloride
Sympathomimetics in glaucoma therapy
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.5M
people
0
abandoned
Apremilast — full profile
Apremilast
Selective immunosuppressants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.7M
people
11
abandoned
Aprepitant — full profile
Aprepitant
Other antiemetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.9M
people
0
abandoned
Arformoterol Tartrate — full profile
Arformoterol Tartrate
Class not recorded
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.5M
people
55
abandoned
Argatroban — full profile
Argatroban
Direct thrombin inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
6.8M
people
54
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.