The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 201240 of 1,208 generic medicines
Armodafinil — full profile
Armodafinil
Centrally acting sympathomimetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
27
abandoned
Arsenic Trioxide — full profile
Arsenic Trioxide
Other antineoplastic agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Ascorbic Acid — full profile
Ascorbic Acid
Ascorbic acid (vitamin C), plain
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Ascorbic Acid; Biotin; Cholecalciferol; Cyanocobalamin; Dexpanthenol; Folic Acid; Niacinamide; Pyridoxine; Riboflavin; Thiamine; Tocopherol Acetate; Vitamin A; Vitamin K — full profile
Ascorbic Acid; Biotin; Cholecalciferol; Cyanocobalamin; Dexpanthenol; Folic Acid; Niacinamide; Pyridoxine; Riboflavin; Thiamine; Tocopherol Acetate; Vitamin A; Vitamin K
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ascorbic Acid; Polyethylene Glycol 3350; Potassium Chloride; Sodium Ascorbate; Sodium Chloride; Sodium Sulfate — full profile
Ascorbic Acid; Polyethylene Glycol 3350; Potassium Chloride; Sodium Ascorbate; Sodium Chloride; Sodium Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Aspirin; Butalbital; Caffeine — full profile
Aspirin; Butalbital; Caffeine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Aspirin; Butalbital; Caffeine; Codeine Phosphate — full profile
Aspirin; Butalbital; Caffeine; Codeine Phosphate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Aspirin; Caffeine; Orphenadrine Citrate — full profile
Aspirin; Caffeine; Orphenadrine Citrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Aspirin; Dipyridamole — full profile
Aspirin; Dipyridamole
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Aspirin; Hydrocodone Bitartrate — full profile
Aspirin; Hydrocodone Bitartrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Atazanavir Sulfate — full profile
Atazanavir Sulfate
Antivirals for treatment of HIV infections, combinations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.4M
people
35
abandoned
Atenolol — full profile
Atenolol
Beta blocking agents, selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
52
abandoned
Atenolol; Chlorthalidone — full profile
Atenolol; Chlorthalidone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Atomoxetine Hydrochloride — full profile
Atomoxetine Hydrochloride
Centrally acting sympathomimetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
24.1M
people
52
abandoned
Atorvastatin Calcium — full profile
Atorvastatin Calcium
Combinations of various lipid modifying agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.8M
people
25
abandoned
Atovaquone — full profile
Atovaquone
Biguanides
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
44
abandoned
Atovaquone; Proguanil Hydrochloride — full profile
Atovaquone; Proguanil Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Atracurium Besylate — full profile
Atracurium Besylate
Other quaternary ammonium compounds
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.6M
people
34
abandoned
Atropine Sulfate — full profile
Atropine Sulfate
Belladonna alkaloids, tertiary amines
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.6M
people
55
abandoned
Atropine Sulfate; Diphenoxylate Hydrochloride — full profile
Atropine Sulfate; Diphenoxylate Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Avanafil — full profile
Avanafil
Drugs used in erectile dysfunction
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.1M
people
2
abandoned
Azacitidine — full profile
Azacitidine
Pyrimidine analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.8M
people
32
abandoned
Azathioprine — full profile
Azathioprine
Other immunosuppressants
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
34
abandoned
Azathioprine Sodium — full profile
Azathioprine Sodium
Other immunosuppressants
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Azelaic Acid — full profile
Azelaic Acid
Other anti-acne preparations for topical use
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Azelastine Hydrochloride — full profile
Azelastine Hydrochloride
Antiallergic agents, excl. corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
25
abandoned
Azelastine Hydrochloride; Fluticasone Propionate — full profile
Azelastine Hydrochloride; Fluticasone Propionate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Azilsartan Kamedoxomil — full profile
Azilsartan Kamedoxomil
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Azilsartan Kamedoxomil; Chlorthalidone — full profile
Azilsartan Kamedoxomil; Chlorthalidone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Azithromycin — full profile
Azithromycin
Macrolides
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
70
abandoned
Aztreonam — full profile
Aztreonam
Monobactams
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
24
abandoned
Bacitracin Zinc; Hydrocortisone; Neomycin Sulfate; Polymyxin B Sulfate — full profile
Bacitracin Zinc; Hydrocortisone; Neomycin Sulfate; Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bacitracin Zinc; Neomycin Sulfate; Polymyxin B Sulfate — full profile
Bacitracin Zinc; Neomycin Sulfate; Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bacitracin Zinc; Polymyxin B Sulfate — full profile
Bacitracin Zinc; Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Baclofen — full profile
Baclofen
Other centrally acting agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.1M
people
17
abandoned
Baloxavir Marboxil — full profile
Baloxavir Marboxil
Other antivirals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Balsalazide Disodium — full profile
Balsalazide Disodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Beclomethasone Dipropionate — full profile
Beclomethasone Dipropionate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Benazepril Hydrochloride — full profile
Benazepril Hydrochloride
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
55
abandoned
Benazepril Hydrochloride; Hydrochlorothiazide — full profile
Benazepril Hydrochloride; Hydrochlorothiazide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.