The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 241280 of 1,208 generic medicines
Bendamustine Hydrochloride — full profile
Bendamustine Hydrochloride
Nitrogen mustard analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.3M
people
0
abandoned
Benzonatate — full profile
Benzonatate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Benzoyl Peroxide; Clindamycin Phosphate — full profile
Benzoyl Peroxide; Clindamycin Phosphate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Benzoyl Peroxide; Erythromycin — full profile
Benzoyl Peroxide; Erythromycin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Benzphetamine Hydrochloride — full profile
Benzphetamine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Benztropine Mesylate — full profile
Benztropine Mesylate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bepotastine Besilate — full profile
Bepotastine Besilate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Betaine — full profile
Betaine
Amino acids and derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Betamethasone Acetate; Betamethasone Sodium Phosphate — full profile
Betamethasone Acetate; Betamethasone Sodium Phosphate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Betamethasone Dipropionate — full profile
Betamethasone Dipropionate
Corticosteroids acting locally
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
17
abandoned
Betamethasone Dipropionate; Calcipotriene — full profile
Betamethasone Dipropionate; Calcipotriene
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Betamethasone Dipropionate; Clotrimazole — full profile
Betamethasone Dipropionate; Clotrimazole
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Betamethasone Valerate — full profile
Betamethasone Valerate
Corticosteroids acting locally
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
48
abandoned
Betaxolol Hydrochloride — full profile
Betaxolol Hydrochloride
Beta blocking agents, selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
27
abandoned
Bethanechol Chloride — full profile
Bethanechol Chloride
Choline esters
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Bexarotene — full profile
Bexarotene
Retinoids for cancer treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.7M
people
56
abandoned
Bicalutamide — full profile
Bicalutamide
Anti-androgens
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
39
abandoned
Bimatoprost — full profile
Bimatoprost
Prostaglandin analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
14
abandoned
Bismuth Subcitrate Potassium; Metronidazole; Tetracycline Hydrochloride — full profile
Bismuth Subcitrate Potassium; Metronidazole; Tetracycline Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bismuth Subsalicylate; Metronidazole; Tetracycline Hydrochloride — full profile
Bismuth Subsalicylate; Metronidazole; Tetracycline Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bisoprolol Fumarate — full profile
Bisoprolol Fumarate
Beta blocking agents, selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
55
abandoned
Bisoprolol Fumarate; Hydrochlorothiazide — full profile
Bisoprolol Fumarate; Hydrochlorothiazide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bivalirudin — full profile
Bivalirudin
Direct thrombin inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
6.8M
people
21
abandoned
Bleomycin Sulfate — full profile
Bleomycin Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bortezomib — full profile
Bortezomib
Proteasome inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.0M
people
63
abandoned
Bosentan — full profile
Bosentan
Antihypertensives for pulmonary arterial hypertension
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.7M
people
0
abandoned
Brimonidine Tartrate — full profile
Brimonidine Tartrate
Other dermatologicals
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.5M
people
32
abandoned
Brimonidine Tartrate; Timolol Maleate — full profile
Brimonidine Tartrate; Timolol Maleate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Brinzolamide — full profile
Brinzolamide
Carbonic anhydrase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.2M
people
9
abandoned
Brivaracetam — full profile
Brivaracetam
Other antiepileptics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.0M
people
25
abandoned
Bromfenac Sodium — full profile
Bromfenac Sodium
Antiinflammatory agents, non-steroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
0
abandoned
Bromocriptine Mesylate — full profile
Bromocriptine Mesylate
Prolactine inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
0
abandoned
Brompheniramine Maleate; Dextromethorphan Hydrobromide; Pseudoephedrine Hydrochloride — full profile
Brompheniramine Maleate; Dextromethorphan Hydrobromide; Pseudoephedrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Budesonide — full profile
Budesonide
Corticosteroids acting locally
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
48
abandoned
Budesonide; Formoterol Fumarate Dihydrate — full profile
Budesonide; Formoterol Fumarate Dihydrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bumetanide — full profile
Bumetanide
Sulfonamides, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.1M
people
25
abandoned
Bupivacaine Hydrochloride — full profile
Bupivacaine Hydrochloride
Amides
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.5M
people
55
abandoned
Bupivacaine Hydrochloride; Epinephrine — full profile
Bupivacaine Hydrochloride; Epinephrine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Bupivacaine Hydrochloride; Epinephrine Bitartrate — full profile
Bupivacaine Hydrochloride; Epinephrine Bitartrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Buprenorphine — full profile
Buprenorphine
Oripavine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
23.3M
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.